Figure 4
From: Predicting and characterizing selective multiple drug treatments for metabolicdiseases and cancer
Nonlinearity in the synergism: the example of Guanylate kinase. The partof the human network here represented shows the nonlinear interaction when thethree drug targets (the three valves, with the name of the drugs) aresimultaneously inhibited: when this is the case, the objective reaction ofGuanylate kinase (in red) is stopped. Gray arrows and gray circles indicaterespectively stopped reactions and metabolites which become unavailable.