Inactivated Protein | DNA damage | Reported effects with functional p53 | References | Model prediction |
---|---|---|---|---|
ATM | DSBs | · cell cycle arrest diminished | Lavin 2008 | · cell cycle arrest blocked |
Bolderson et al. 2009 | · anti-apoptotic NF-κB (p50-p65-P) blocked | |||
· cell death enhanced | ||||
· apoptosis diminished | ||||
Tofilon and Camphausen 2009 | ||||
ATR | SSBs | · cell death enhanced | Flatten et al. 2005 | · cell cycle arrest diminished |
Wagner and Kaufmann 2010 | ||||
Chk1 | SSBs | · cell cycle arrest diminished | Tse et al. 2007 | · Cdc25A degradation diminished (degradation of Cdc25A leads to cell cycle arrest) |
Ma et al. 2011 | ||||
· cell death enhanced | · p53 activation (causes apoptosis or cell cycle arrest) diminished | |||
Garret and Collins 2011 | ||||
Chk2 | DSBs | cell death reduced | Morgan et al. 2010 | · cell cycle arrest diminished |
Ma et al. 2011 | ||||
· apoptosis diminished | ||||
Garret and Collins 2011 | · p53 activation (causes apoptosis or cell cycle arrest) diminished | |||
TAK1 | SSBs | · cell death enhanced | Martin et al. 2011 | · cell cycle arrest diminished |