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Table 1 Parameters of ER binding with ligands and DNA ERE

From: A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen

Reaction Kd Value in the model, nM Existing experimental estimates, nM Reference
ER+ER=ER2 K1 25 >50 [73]
ER2+H=ER2H K2 0.2 0.16 [23]
ER2H+H=ER2H2 K3 0.1 -  
ER+H=ERH K4 0.25 0.9 [31]
ERH+ER=ER2H K5* 20 50 [73]
ERH+ERH=ER2H2 K6* 8 4 [33]
    20 [73]
ER2+I=ER2I K7 10 -  
ER2I+I=ER2I2 K8 150 220 [31]
ER+I=ERI K9 30 -  
ERI+ER=ER2I K10* 8.3 < K5 [23]
ERI+ERI=ER2I2 K11* 41.5 -  
ERH+ERI=ER2HI K12* 26.67 -  
ER2I+H=ER2HI K13 0.8 -  
ER2H+I=ER2HI K14* 40 -  
ER2+D=ER2D K15 8 40 [35]
    2.5 [36]
ER2H+D=ER2HD K16 2.4 -  
ER2H2+D=ER2H2D K17 1.2 1.8 ±0.6 [36]
    2.0±0.3 [27];
    10 [35]
ER2I+D=ER2ID K18 50 -  
ER2I2+D=ER2I2D K19 87 14 [37]
ER2HI+D=ER2HID K20 10-20 -  
  1. Parameters marked by (*) are dependent on the values of others and have been calculated as described in Methods.