Figure 8From: Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approachSimulation of influence of glutathione on production of 5-LO metabolites (sum of LTA4, HP and HT). Parameters of the LOS model used for simulation: pool of NADP 3 mM; NADPH 2 mM; Ca 1 mM; 5-LO 0.1 μM; HEDH5 0.1 μM; Values of parameter PL responsible for steady state AA level are 117 (solid), 120 (dash), 125 (dot).Back to article page