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Table 1 Kinetic parameters of enzyme catalytic cycles

From: Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach

Parameter Value Units
V max PLA 2 450 μM/min
K m PLA 2 _ APC 20 μM
K Ca PLA 2 0.1 μM
K AA 10.7 μM
K 2 Ca 7.11 mM
K 2 Ca 14.4 μM
K ox 100 μM
K r 5.8 10-7 -
K AA i 552 μM
K HT 0.54 μM
K d3 1.3 10-4 -
k lo 4.6 103 1/min
k 3 0.34 103 (min· μM)-1
k ox 2.7 10-4 (min· μM)-1
k ox2 67.2 (min· μM)-1
k r 2.54 10-4 1/min
k r2 4.4 10-5 1/min
k LTAsyn 5.4 10-4 1/min
k ing 16450 1/min
K dz 36.6 μM
K PF 0.126 uM
K GSSG gpx 0.072 μM
k cat gpx 0.489 1/min
K NADP hedh 2.9 μM
K NADPH hedh 2.69 μM
K oxoETE hedh 1.67 μM
K HT hedh 0.332 μM
k 1 hedh 88.34 1/min
k 2 hedh 1724 1/min
k - 1 hedh 31.5 1/min
k - 2 hedh 8.08 1/min
k HTd 0.001 1/min
k LTAd 0.07 1/min
k oxoETEd 0.005 1/min