Table 3 Potency of 5-LO inhibitors in whole blood from control (Normal) and asthmatic human volunteer[18]
| Â | CONTROL | ASTHMATICS | ||||||
|---|---|---|---|---|---|---|---|---|
IC50 (nM) | IC80 (nM) | IC50 (nM) | IC80 (nM) | |||||
Experim. | Model | Experim. | Model | Experim. | Model | Experim. | Model | |
Zileuton | 850 ± 220 | 860 | 2270 ± 710 | 3330 | 1080 ± 220 | 860 | 2520 ± 1010 | 3270 |
PF-4191834 | 120 ± 10 | 125 | 300 ± 20 | 518 | 180 ± 20 | 143 | 390 ± 50 | 550 |