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Table 3 Potency of 5-LO inhibitors in whole blood from control (Normal) and asthmatic human volunteer[18]

From: Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach

  CONTROL ASTHMATICS
IC50 (nM) IC80 (nM) IC50 (nM) IC80 (nM)
Experim. Model Experim. Model Experim. Model Experim. Model
Zileuton 850 ± 220 860 2270 ± 710 3330 1080 ± 220 860 2520 ± 1010 3270
PF-4191834 120 ± 10 125 300 ± 20 518 180 ± 20 143 390 ± 50 550