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Table 4 Parameter estimations of the L. lactis model

From: Incremental parameter estimation of kinetic metabolic network models

  Simultaneous method Incremental method
  min Φ C a min Φ S min Φ C min Φ S
CPU time (sec) >5 days 3476.89 ± 349.63 976.72 ± 31.01 20.82 ± 2.71
eSSM GO iterations 1662 ± 282 4 ± 1 33 ± 7
Φ C Stiff ODE 2.20 ± 8.81 × 10-3 6.18 ± 7.28 × 10-2
Φ S 2.67 ± 1.93 × 10-4 1.51 × 103 ± 52.50 5.79 ± 9.62 × 10-4
  1. a. None of five runs finished with a relative improvement of the objective function below 1% within the 5-day time limit, after iterating for 60, 147, 93, 79 and 31 times. The corresponding Φ C at termination were 9.31, 7.57, 8.77, 9.39 and 12.9, respectively.