Skip to main content

Table 1 Detailed information about the DETFs

From: The extended TILAR approach: a novel tool for dynamic modeling of the transcription factor network regulating the adaption to in vitro cultivation of murine hepatocytes

DETF Cluster Associated biological processes
Atf3 5 gluconeogenesis; regulation of cell proliferation
Cebpa 4 liver development; fat cell differentiation; regulation of cell proliferation; urea cycle
Cebpb 6 cell differentiation; anti-apoptotic
Cebpd 4 fat cell differentiation
Csrnp1 5 apoptotic process; platelet-derived growth factor receptor signaling pathway
Dbp 6 rhythmic processes
E2f6 2 regulation of transcription involved in G1/S phase of mitotic cell cycles;
Egr1 6 BMP signaling; Il1 mediated signaling pathway; regulation of Wnt signaling pathway; regulation of cell-death; response to glucose stimulus; response to insulin stimulus
Fos 6 cellular response to extracellular stimuli; response to stress
Foxa1 2 glucose homeostasis; chromatin remodeling
Gatad1 2 -
Id3 3 regulation of cell cycle; regulation of apoptosis
Irf1 3 cellular response to Il1; regulation of cell-death
Klf16 6 -
Maff 5 epidermal cell-differentiation
Nr1h4 2 bile acid metabolic process; regulation of carbohydrate- and urea metabolic process;
Ppara 4 Glucose metabolic process; lipid metabolic process; response to insulin stimulus
Srebf1 4 Steroid metabolic process; response to glucose stimulus; lipid metabolic process;
Srf 4 actin filament organization; cell-cell adhesion; developmental growth;
Tgif1 3 regulation of cell proliferation; regulation of retinoic acid receptor signaling pathway
Tsc22d1 2 regulation of apoptotic process; regulation of cell proliferation
Zbtb16 4 positive regulation of apoptosis; negative regulation of proliferation
  1. DETF cluster membership and associated biological functions based on the information of GeneOntology. For all but Gatad1 and Klf16 it was found that the TFs can either be associated with metabolic processes and/or cell faith.