Clustering of time-resolved fractional appearance profiles. Shown are the fractional appearance profiles of reactions over time. Under both (A) cold and (B) heat shock, the selected reactions group into 9 clusters. Enzyme names discussed in the text are given. A complete list of all enzyme names is given in the Additional file1: Table S3. In both stresses clusters 7 and 9 represent metabolic reactions that are constantly active, most of them crucial for viability. All other clusters represent reactions that undergo (de)activation and are likely involved in stress response. Note: For better visualization, identical profiles are slightly shifted. Reference value is given by the profile appearing on the bottom.