(A) Scatter plot of partition score H
and modularity score V
for all reaction pairs [i, j] in the Day 12 flux-weighted model. A red box is drawn around reaction pairs with Hij > 0.7 and Vij > 3.0. (B) Heat map showing the number of models (Day 4, Day 12, Day 12 with LDH inhibition, Day 12 with PCX inhibition) for which a reaction pair [i, j] has a high partition score and a high modularity score (Hij > 0.7 and Vij > 3.0). A reaction pair was designated as robust if Hij > 0.7 and Vij > 3.0 in all four models. The robust reaction pairs are shown as black squares in the heat map. (C) Scatter plot of partition score Hij and modularity score Vij for all reaction pairs [i, j] in the un-weighted model. The red asterisks denote the 17 robust reaction pairs identified in panel (B).