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Table 1 The list of prioritized L. major targets

From: Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease

L. majortargets Enzyme name E.C. Metabolic pathway(s) Sub-cellular localization(s)† Druggability Growth defect* No. of drugs
LmjF04.0580 spermidine synthase 2.5.1.16 methionine metabolism cytosol 0.8 100% (L) 3
LmjF05.0350 trypanothione reductase 1.8.1.12 trypanothione metabolism glycosome 0.9 100% (L) 45
LmjF05.0830 methylthioadenosine phosphorylase 2.4.2.28 methionine metabolism cytosol 0.8 100% (L) 15
LmjF06.0650 lanosterol synthase 5.4.99.7 steroid biosynthesis ER 0.6 100% (L) 3
LmjF11.1100 sterol 14-demethylase 1.14.13.70 steroid biosynthesis ER 0.8 100% (L) 133
LmjF12.0280 ornithine decarboxylase 4.1.1.17 urea cycle and metabolism of amino groups cytosol 1 100% (L) 40
LmjF13.1620 squalene monooxygenase 1.14.99.7 steroid biosynthesis ER 0.8 100% (L) 14
LmjF18.0020 diphosphomevalonate decarboxylase 4.1.1.33 steroid biosynthesis glycosome/cytosol 0.6 100% (L) 5
LmjF22.1360 dimethylallyltranstransferase geranyltranstransferase 2.5.1.1 2.5.1.10 steroid biosynthesis glycosome/cytosol 0.8 100% (L) 11
LmjF25.1120 aldehyde dehydrogenase 1.2.1.3 many pathways mitochondria 1 > 30% (GR) 28
LmjF30.3190 hydroxymethylglutaryl CoA reductase 1.1.1.34 steroid biosynthesis glycosome/mitochondria 0.8 100% (L) 29
LmjF31.2940 squalene synthase 2.5.1.21 steroid biosynthesis glycosome/cytosol 0.8 100% (L) 9
LmjF32.1580 phosphomannose isomerase 5.3.1.8 fructose and mannose metabolism cytosol 0.6 100% (L) 5
LmjF33.2720 beta-ketoacyl-acyl-carrier-protein synthase I 2.3.1.41 fatty acid biosynthesis mitochondria 0.7 100% (L) 5
LmjF35.3340 phosphogluconate dehydrogenase 1.1.1.44 pentose phosphate pathway cytosol 0.8 100% (L) 13
  1. * (L) Lethal, (GR) Growth-reducing; † (ER) Endoplasmic Reticulum