Table 1 The list of prioritized L. major targets
L. majortargets | Enzyme name | E.C. | Metabolic pathway(s) | Sub-cellular localization(s)†| Druggability | Growth defect* | No. of drugs |
|---|---|---|---|---|---|---|---|
LmjF04.0580 | spermidine synthase | 2.5.1.16 | methionine metabolism | cytosol | 0.8 | 100% (L) | 3 |
LmjF05.0350 | trypanothione reductase | 1.8.1.12 | trypanothione metabolism | glycosome | 0.9 | 100% (L) | 45 |
LmjF05.0830 | methylthioadenosine phosphorylase | 2.4.2.28 | methionine metabolism | cytosol | 0.8 | 100% (L) | 15 |
LmjF06.0650 | lanosterol synthase | 5.4.99.7 | steroid biosynthesis | ER | 0.6 | 100% (L) | 3 |
LmjF11.1100 | sterol 14-demethylase | 1.14.13.70 | steroid biosynthesis | ER | 0.8 | 100% (L) | 133 |
LmjF12.0280 | ornithine decarboxylase | 4.1.1.17 | urea cycle and metabolism of amino groups | cytosol | 1 | 100% (L) | 40 |
LmjF13.1620 | squalene monooxygenase | 1.14.99.7 | steroid biosynthesis | ER | 0.8 | 100% (L) | 14 |
LmjF18.0020 | diphosphomevalonate decarboxylase | 4.1.1.33 | steroid biosynthesis | glycosome/cytosol | 0.6 | 100% (L) | 5 |
LmjF22.1360 | dimethylallyltranstransferase geranyltranstransferase | 2.5.1.1 2.5.1.10 | steroid biosynthesis | glycosome/cytosol | 0.8 | 100% (L) | 11 |
LmjF25.1120 | aldehyde dehydrogenase | 1.2.1.3 | many pathways | mitochondria | 1 | > 30% (GR) | 28 |
LmjF30.3190 | hydroxymethylglutaryl CoA reductase | 1.1.1.34 | steroid biosynthesis | glycosome/mitochondria | 0.8 | 100% (L) | 29 |
LmjF31.2940 | squalene synthase | 2.5.1.21 | steroid biosynthesis | glycosome/cytosol | 0.8 | 100% (L) | 9 |
LmjF32.1580 | phosphomannose isomerase | 5.3.1.8 | fructose and mannose metabolism | cytosol | 0.6 | 100% (L) | 5 |
LmjF33.2720 | beta-ketoacyl-acyl-carrier-protein synthase I | 2.3.1.41 | fatty acid biosynthesis | mitochondria | 0.7 | 100% (L) | 5 |
LmjF35.3340 | phosphogluconate dehydrogenase | 1.1.1.44 | pentose phosphate pathway | cytosol | 0.8 | 100% (L) | 13 |