Figure 2From: Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networksDistribution of structural and functional annotations in the Ensemble network. Distribution of node Degree (A) and Pathway Maps (number of pathways a given gene is annotated as being involved in) (B). These two metrics are plotted against Betweeness (C and D respectively) for all 2,361 genes comprising the network. The Pathway Maps vs. Betweeness distribution is separated into 3 regions; MapshiBThi, MapsloBThi, and MapsloBTlo, color-coded blue, red, and green respectively (D). Hypergeometric Z Scores quantify the enrichment of Kinases, Transcription factors, and Generic binding proteins across the 3 respective topological regions. Z-Scores are first computed for the top 10 genes comprising the tip of the region (n = 10), and the sample window (n/N) is then successively widened across the entire network, and scores iteratively computed to evaluate the distribution of protein function vs. topology. Z-Scores greater than 2 correspond to P-values less than 0.05 (E).Back to article page