Table 9 Predicted genes for the most feasible FN-correcting SMILEY solutions

ASP1DC

I

ASPT

III

reversible (Karsten and Viola [38])

ICL

IV

reversible (MacKintosh and Nimmo [38])

AKGDH

IV

not reversible (EcoCyc)

CITL

IV

Hypothesized gap-filling reactions

Reaction

Category

Putative gene

E-value

R00352 (R)

IV

sucD (b0729)

2.00E-20

R00373 (F)

I

global orphan

R00400 (F)

I

global orphan

R00507 (R)

IV

yhfW (b3380)

0.47

R00529 (F)

IV

cysN (b2751) and cysD (b2752) *

R00530 (F)

IV

global orphan

R00531 (R)

IV

global orphan

R00695 (R)

I

global orphan

R00709 (F)

IV

dmlA (b1800)

6.00E-26

icd (b1136)

1.00E-26

leuB (b0073)

2.00E-15

R00732 (R)

III

aroA (b0908)

5.00E-32

murA (b3189)

7.00E-8

R00733 (R)

III

tyrA (b2600)

2.80E-2

R01393 (R)

I

global orphan

R01618 (R)

IV

glgP (b3428)

2.10

R01713 (F)

I

global orphan

R01731 (F)

IV

tyrB (b4054) *

R01785 (R)

III

rhaD (b3902) *

R01902 (R)

III

rhaB (b3904) *

R02200 (F)

IV

global orphan

R04209 (R)

IV

purC (b2476)

7.00E-16

R05717 (R)

IV

cysH (b2762)

3.00E-12

R06613 (F)

II

ybiU (b0821)

1.6

R07164 (R)

III

ydiJ (b1687)

0.9

R07165 (R)

III

ydiJ (b1687)

0.9

R07176 (R)

IV

global orphan

R07463 (F)

IV

dadA (b1189)

2.00E-18

R07613 (R)

II

ydbL (b0600)

7.00E-26

ydcR (b1439)

6.00E-15

R08553 (R)

IV

ysaA (b3573)

4.00E-5