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Table 4 Top 25 hub genes with a degree (deg) larger than 20 found in the B-cell lymphoma gene regulatory network - genes are described by their Entrez gene id, gene symbol, and, if available, one selected annotation term from GO (category Biological Process), bc refers to the betweenness centrality and the number in brackets to its rank with respect to the bc values

From: Organizational structure and the periphery of the gene regulatory network in B-cell lymphoma

Entrez Symbol deg/bc(rank) Description
778 CACNA1F 46/282019(1) calcium channel, voltage-dependent, L type, alpha 1F subunit (calcium ion transport GO:0006816)
2949 GSTM5 38/14454(39) glutathione S-transferase mu 5 (metabolic process GO:0008152)
7275 TUB 37/16818(35) tubby homolog (mouse) (response to stimulus GO:0050896)
9080 CLDN9 35/65406(6) claudin 9 (calcium-independent cell-cell adhesion GO:0016338)
3363 HTR7 33/1436(406) 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) (signal transduction GO:0007165)
1579 CYP4A11 32/24724(25) cytochrome P450, family 4, subfamily A, polypeptide 11 (long-chain fatty acid metabolic process GO:0001676)
796 CALCA 32/46142(11) calcitonin-related polypeptide alpha (endothelial cell proliferation GO:0001935)
7546 ZIC2 28/6978(95) Zic family member 2 (odd-paired homolog, Drosophila) (cell differentiation GO:0030154)
1993 ELAVL2 28/9991(62) ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) ( NA)
1549 CYP2A7 27/33469(17) cytochrome P450, family 2, subfamily A, polypeptide 7 (oxidation-reduction process GO:0055114)
5554 PRH1 27/8093(77) proline-rich protein HaeIII subfamily 1 ( NA)
2516 NR5A1 27/248679(2) nuclear receptor subfamily 5, group A, member 1 (cell-cell signaling GO:0007267)
11222 MRPL3 27/12748(45) mitochondrial ribosomal protein L3 (translation GO:0006412)
92017 SNX29 26/159597(3) sorting nexin 29 (cell communication GO:0007154)
6534 SLC6A7 25/46858(10) solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 (proline transport GO:0015824)
115703 ARHGAP33 25/28006(21) Rho GTPase activating protein 33 (signal transduction GO:0007165)
40 ACCN1 24/5548(113) amiloride-sensitive cation channel 1, neuronal (sodium ion transport GO:0006814)
1943 EFNA2 23/34712(16) ephrin-A2 (cell-cell signaling GO:0007267)
7047 TGM4 23/147229(4) transglutaminase 4 (prostate) (peptide cross-linking GO:0018149)
343 AQP8 22/17440(34) aquaporin 8 (water transport GO:0006833)
9127 P2RX6 22/63918(7) purinergic receptor P2X, ligand-gated ion channel, 6 (signal transduction GO:0007165)
2797 GNRH2 21/2976(202) gonadotropin-releasing hormone 2 (signal transduction GO:0007165)
5545 PRB4 21/9246(66) proline-rich protein BstNI subfamily 4 ( NA)
4706 NDUFAB1 21/11907(49) NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa (electron transport chain GO:0022900)
553 AVPR1B 21/5080(130) arginine vasopressin receptor 1B (signal transduction GO:0007165)