Table 4 Top 25 hub genes with a degree (deg) larger than 20 found in the B-cell lymphoma gene regulatory network - genes are described by their Entrez gene id, gene symbol, and, if available, one selected annotation term from GO (category Biological Process), bc refers to the betweenness centrality and the number in brackets to its rank with respect to the bc values
From: Organizational structure and the periphery of the gene regulatory network in B-cell lymphoma
Entrez | Symbol | deg/bc(rank) | Description |
|---|---|---|---|
778 | CACNA1F | 46/282019(1) | calcium channel, voltage-dependent, L type, alpha 1F subunit (calcium ion transport GO:0006816) |
2949 | GSTM5 | 38/14454(39) | glutathione S-transferase mu 5 (metabolic process GO:0008152) |
7275 | TUB | 37/16818(35) | tubby homolog (mouse) (response to stimulus GO:0050896) |
9080 | CLDN9 | 35/65406(6) | claudin 9 (calcium-independent cell-cell adhesion GO:0016338) |
3363 | HTR7 | 33/1436(406) | 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) (signal transduction GO:0007165) |
1579 | CYP4A11 | 32/24724(25) | cytochrome P450, family 4, subfamily A, polypeptide 11 (long-chain fatty acid metabolic process GO:0001676) |
796 | CALCA | 32/46142(11) | calcitonin-related polypeptide alpha (endothelial cell proliferation GO:0001935) |
7546 | ZIC2 | 28/6978(95) | Zic family member 2 (odd-paired homolog, Drosophila) (cell differentiation GO:0030154) |
1993 | ELAVL2 | 28/9991(62) | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) ( NA) |
1549 | CYP2A7 | 27/33469(17) | cytochrome P450, family 2, subfamily A, polypeptide 7 (oxidation-reduction process GO:0055114) |
5554 | PRH1 | 27/8093(77) | proline-rich protein HaeIII subfamily 1 ( NA) |
2516 | NR5A1 | 27/248679(2) | nuclear receptor subfamily 5, group A, member 1 (cell-cell signaling GO:0007267) |
11222 | MRPL3 | 27/12748(45) | mitochondrial ribosomal protein L3 (translation GO:0006412) |
92017 | SNX29 | 26/159597(3) | sorting nexin 29 (cell communication GO:0007154) |
6534 | SLC6A7 | 25/46858(10) | solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 (proline transport GO:0015824) |
115703 | ARHGAP33 | 25/28006(21) | Rho GTPase activating protein 33 (signal transduction GO:0007165) |
40 | ACCN1 | 24/5548(113) | amiloride-sensitive cation channel 1, neuronal (sodium ion transport GO:0006814) |
1943 | EFNA2 | 23/34712(16) | ephrin-A2 (cell-cell signaling GO:0007267) |
7047 | TGM4 | 23/147229(4) | transglutaminase 4 (prostate) (peptide cross-linking GO:0018149) |
343 | AQP8 | 22/17440(34) | aquaporin 8 (water transport GO:0006833) |
9127 | P2RX6 | 22/63918(7) | purinergic receptor P2X, ligand-gated ion channel, 6 (signal transduction GO:0007165) |
2797 | GNRH2 | 21/2976(202) | gonadotropin-releasing hormone 2 (signal transduction GO:0007165) |
5545 | PRB4 | 21/9246(66) | proline-rich protein BstNI subfamily 4 ( NA) |
4706 | NDUFAB1 | 21/11907(49) | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa (electron transport chain GO:0022900) |
553 | AVPR1B | 21/5080(130) | arginine vasopressin receptor 1B (signal transduction GO:0007165) |