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Table 1 Metabolic fluxes in the network model used for data simulation

From: Rational design of 13C-labeling experiments for metabolic flux analysis in mammalian cells

Flux

Wild type (WT)

PC cells (PYC)

Gluc.ext → G6P

1.00

1.00

G6P → R5P + CO2

0.29

0.08

GAP → Pyr

1.88

1.93

Pyr → Lac

0.95

0.30

OAC + AcCoA → AKG + CO2

0.89

1.88

Pyr + CO2 → OAC

0.00

0.84

Mal → OAC

0.89

1.10

Mal → Pyr + CO2

0.15

1.11

  1. Fluxes were taken from Henry et al. and were normalized to glucose uptake. Fluxes are shown for wild-type HEK-293 cells (WT) and HEK-293 cells expressing yeast pyruvate carboxylase (PYC).
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BMC Systems Biology

ISSN: 1752-0509

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