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Table 4 Top 10 up-regulated glycoproteins in SaOS-2/LM7 model

From: A systems biology approach reveals common metastatic pathways in osteosarcoma

Gene

Symbol

Accession #

LM7/

SaOS-2

p-value

Unique Peptides

Function

VIM

IPI00418471

350

1 x

10E-42

22

Filaments expressed in neoplasms originated from mesenchymal cells

TPM1

IPI00940084

130

2.2 x 10E-41

2

Contractile system of muscles and the cytoskeleton of non-muscle cells

ALB

IPI00022434

120

2 x

10E-38

9

Primarily a carrier protein in serum

ODZ3

IPI00398020

97

1.1 x 10E-30

2

May function as signal transducer

KRT5

IPI00009867

90

1.4 x 10E-28

2

Filaments found in basal layer of epidermis

WDR49

IPI00216853

86

2.7 x 10E-27

2

Regulates cell division, cell-fate determination, gene transcription, and transmembrane signaling

A2M

IPI00478003

84

1.9 x 10E-26

6

Inhibits all classes of proteinases by a unique 'trapping' mechanism

NES

IPI00010800

81

1.3 x 10E-25

16

Disassembly of vimentin, role in the trafficking and distribution of cellular factors during progenitor cell division

CAL2

IPI00916600

70

3.4 x 10E-22

3

Mediates the control of numerous enzymes and proteins by calcium

ANXA5

IPI00329801

58

2.4 x 10E-18

6

Anticoagulant, inhibitor of the thromboplastin-specific complex