Figure 1

Illustration of how two TFs can cooperatively regulate a gene. Results are shown for a putative target gene FBgn0036752 that is highly ranked as a joint target of the TFs Bagpipe (BAP) and Myocyte enhancer factor 2 (MEF2) by the proposed method. Red crosses show target gene expression data (12 time points) from[33] and blue lines show model predictions and associated credible regions. In the top row we show the activity profiles for each TF which are inferred during the training phase by fitting a regulation model on a network of known structure. In the bottom row we show the model fit during genome-wide scanning for this target gene. We show the target mRNA concentration profile inferred by fitted models of (a) regulation by BAP only, (b) regulation by MEF2 only and (c) regulation by BAP and MEF2. The candidate gene is confirmed as a joint target by independent ChIP-chip studies[12].