Figure 7
Enrichment of binding of predicted regulator TFs near genes. The plots show the percentage enrichment of top-ranking genes with ChIP-chip evidence of binding of all the predicted regulators. In (a) only genes with exactly correct binding profile (both positives and negatives) are considered correct predictions. In (b) only positive predictions are required to be correct and additional bound TFs are ignored, but genes predicted to be unregulated are ignored completely. Genes are ranked by the posterior probability of the most likely model. The compared methods are the posterior probability over all 32 models (dark blue bars), the maximum likelihood-based baseline method (light blue bars), the Regression method (yellow bars) and the Inferelator (red bars), which are compared to predicting regulators uniformly at random (blue line; link probability 0.5). As the Inferelator offers no clear method for ranking the genes, its results are only shown for all 6003 genes. p-values of results statistically significantly different from random are denoted by ‘***’: p < 0.001, ‘**’: p < 0.01, ‘*’: p < 0.05.