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Table 2 Feature analysis of proteins in unstable class

From: Mapping the stabilome: a novel computational method for classifying metabolic protein stability

Unstable vs  Stable Plus Non-Assigned
Domain/Motif E-value
Transmembrane 3.75e-96 ‡
Signal Peptide 9.15e-50 ‡
Loops/Coils 1.36e-06
Immunoglobulin 1.77e-04
Immunoglobulin Like 2.01e-03 ‡
Immunoglobulin C 4.286e-03 ‡
Zinc Finger C2 1.73e-02
Cadherin 2.39e-02 ‡
Phosphorylation 2.29e-15
Acetylation 6.15e-13
Glycosylation 9.73e-04 ‡
Hot loops: 0-20% 8.77e-03 ‡
Loops/Coils: 20-40% 1.06e-03
Hot loops: 20-40% 9.11e-06
Rem465: 20-40% 3.41e-05
N-degron 4.86e-80 ‡
  1. Feature types found to be significantly (Fisher’s Exact test, E-value < 0.05) over-/under-represented in the unstable protein class when compared to stable and non-assigned proteins. E-values for over-represented features are indicated with the symbol ‡, otherwise the E-value represents an under-representation. Features include domain/architecture types, PTMs, and disorder classifications based on three disorder types (loops/coils, hotloops and rem465) and percentage of sequence containing the disorder type. Lastly, the presence of a destabilizing N-terminal residue is shown, defined as the N-terminal residue of a mature protein being one of R, K, H, F, L, W, I or Y. These results are from the full data set (without removal of transmembrane or secreted proteins).