Skip to main content

Advertisement

Table 4 Summary of simulation results of Prototype Model 1

From: A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells

Conditions of differentiation induction Induced cell population Evidence
Exogenous polarizing signals alone No induction of differentiation [18]
Low dose of antigenic stimulant (TCR signal <1 units) and exogenous polarizing signals Homogeneous differentiation (induced phenotype corresponds to type of polarizing signal) [18]
Antigenic stimulant in the presence of IL-4 Heterogeneous differentiation of TH1 and TH2 [18, 21]
Increasing strengths of TCR signal A spectrum of heterogeneous populations with increasing percentages of TH2 cells and decreasing percentage of TH1 cells. [20]
Increasing strengths of TCR signal in the presence of IL-4 A spectrum of heterogeneous populations with increasing percentages of TH2 cells and decreasing percentage of TH1 cells. [18]
TCR signal alone vs. TCR signal with IL-4 Stronger TCR signal is required to achieve a balanced population of TH1 and TH2 in condition without IL-4 than in condition with IL-4 Prediction
TCR signal + TH1 polarizing signals Double-positive phenotype can be observed (via reprogramming from TH2 cells) [24]
TCR signal + TH1 polarizing signals Direct induction of double-positive phenotype can be achieved with strong TCR signal and TH1 polarizing condition Prediction
Blocking GATA3-IL4 feedback by antibodies against IL-4 and inducing with TCR signal No TH2 cells are observed [59]
Blocking GATA3-IL4 feedback by antibodies against IL-4 and inducing with TCR signal Homogeneous differentiation of TH1 cells Prediction