Figure 6
From: Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease
Distribution of free and used APP within monomer and dimer processing in each compartment. Simulations of the influence of intermediate levels of SORLA on APP processing into the amounts of APP concentrations in the TGN (A-E), at the cell surface (F-I), in the endosomes (J-M), and in all the three compartments (N-Q). The term “used” refers to the complex formation of (i) APP and SORLA in the TGN, (ii) APP and α-secretase at the cell surface, and (iii) APP and β-secretase in the endosomes. Wherein, the term “free” refers to the APP that is not bound in the respective compartments. There are five intermediate levels of SORLA, namely, 0% (solid line), 3%, 12%, 30%, and 100% (dashed line) of SORLATot (where SORLATot = 2.43 x 105 fmol). If the dashed line is not seen in a plot, it is because the solid and dashed lines are superimposed. In the first column, there shows the amount of initial APP concentrations that are left free from the monomer and dimer processing (A). Next, in the second and third columns, the amounts of APP concentrations that are free and used in monomer processing are shown, respectively. Then, in the last two columns, the amounts of APP concentrations that are free and used in dimer processing are also given. Notice that SORLA has minimal or no influence on APP in monomer processing (2nd and 3rd columns); conversely, SORLA shows strong influence on APP in dimer processing (last two columns).