Figure 5

Jackknife curves of ION and eight other existing centrality methods. The x-axis represents the proteins in PPI network ranked by ION and eight other existing centrality methods, ranked from left to right as strongest to weakest prediction of essentiality. The Y-axis is the cumulative count of essential proteins encountered moving left to right through the ranked. The areas under the curve for ION and the eight other existing centrality methods are used to compare their prediction performance. In addition, the 10 random assortments are also plotted for comparison. (a) shows the comparison results of ION, PeC, NC and DC. (b) shows the comparison results of ION and two global centrality methods: BC and CC. (c) shows the comparison results of ION and other three centrality methods: IC, EC and SC.