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Table 2 Description of the mammalian circadian clock model state variables

From: Multi-way metamodelling facilitates insight into the complex input-output maps of nonlinear dynamic models

State variable name Unit Description
M P nM Concentration of Per mRNA
B N nM Concentration of non-phosphorylated Bmal1 protein in the nucleus
M C nM Concentration of Cry mRNA
M B nM Concentration of Bmal1 mRNA
P C nM Concentration of non-phosphorylated Per protein in the cytosol
P CP nM Concentration of phosphorylated Per protein in the cytosol
PC C nM Concentration of non-phosphorylated Per-Cry protein complex in the cytosol
C C nM Concentration of non-phosphorylated Cry protein in the cytosol
C CP nM Concentration of phosphorylated Cry protein in the cytosol
PC CP nM Concentration of phosphorylated Per-Cry protein complex in the cytosol
PC N nM Concentration of non-phosphorylated Per-Cry protein complex in the nucleus
PC NP nM Concentration of phosphorylated Per-Cry protein complex in the nucleus
I N nM Concentration of inactive complex between Per-Cry and Clock-Bmal1 in the nucleus
B C nM Concentration of non-phosphorylated Bmal1 protein in the cytosol
B CP nM Concentration of phosphorylated Bmal1 protein in the cytosol
B NP nM Concentration of phosphorylated Bmal1 protein in the nucleus
  1. The 16 state variables correspond to the 16 ODEs in the mammalian circadian clock model.