Figure 2

Spatial distributions of progenitor cells and the crypt growth are driven by a Turing pattern of Wnt signaling. (A) Dynamics of the crypt growth colored in progenitor cell density at three different times. The solution is close to the steady state at T = 100. (B) Concentrations of Wnt, Wnt Inhibitor, BMP, progenitor cells, and TD cells along the crypt direction of s near the steady state at T = 100 (Wnt – magenta solid line, Wnt Inhibitor – black dash line). (C) Time evolution of the progenitor cells. Parameters used are listed in Additional file 1: Table S1 and Table S2.