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Table 2 The proportions of enhancers that underwent selection based on mouse-rat alignments (neutral reference: intron sites)

From: Natural selection drives rapid evolution of mouse embryonic heart enhancers

  Total Under selectiona Positively selectedb Under selectiona/Total Positively selectedb/Under selectiona Positively selectedb/Total
HT 2475 1222 428 49.37% 35.02% 17.29%
FB 1159 748 83 64.53% 11.09% 7.16%
MB 1218 720 147 59.11% 20.41% 12.06%
LB 2470 1449 301 58.66% 20.77% 12.18%
  1. FB: forebrain; MB: midbrain; LB: limb; HT: heart.
  2. aA significantly unequal proportion of substituted sites were observed between enhancers and the intron sites of the neighboring gene by Fisher's exact test.
  3. bEnhancers that underwent selection and had a higher substitution rate than the intron sites of the neighboring gene.