Natural selection drives rapid evolution of mouse embryonic heart enhancers

BMC Systems Biology

Table 2 The proportions of enhancers that underwent selection based on mouse-rat alignments (neutral reference: intron sites)

	Total	Under selection^a	Positively selected^b	Under selection^a/Total	Positively selected^b/Under selection^a	Positively selected^b/Total
HT	2475	1222	428	49.37%	35.02%	17.29%
FB	1159	748	83	64.53%	11.09%	7.16%
MB	1218	720	147	59.11%	20.41%	12.06%
LB	2470	1449	301	58.66%	20.77%	12.18%

FB: forebrain; MB: midbrain; LB: limb; HT: heart.
^aA significantly unequal proportion of substituted sites were observed between enhancers and the intron sites of the neighboring gene by Fisher's exact test.
^bEnhancers that underwent selection and had a higher substitution rate than the intron sites of the neighboring gene.

ISSN: 1752-0509