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Table 8 ORS r (M t ) scores with several threshold regulators

From: MISCORE: a new scoring function for characterizing DNA regulatory motifs in promoter sequences

  

ORS r (M t ), θ= R(S t ) + std(S t ) λ

TF

L fg (bp)

λ = -0.25,

λ = 0.0,

λ = 0.25,

λ = 0.5

CREB

200

0.391

0.357

0.429

0.537

 

500

0.762

0.576

0.884

0.806

SRF

200

0.040

0.048

0.055

0.059

 

500

0.107

0.108

0.126

0.144

TBP

200

0.334

0.385

0.441

0.548

 

500

0.671

0.778

0.793

0.803

MEF2

200

0.041

0.050

0.065

0.100

 

500

0.129

0.177

0.392

0.655

MYOD

200

0.292

0.289

0.289

0.289

 

500

0.303

0.620

0.710

0.746

  1. Remark: MISCORE-based over-representation scores ORS r (.) are computed for each dataset with different thresholds. ORS r (M t ) < 1 holds for all cases, indicating that the background rareness and the over-representation of functional motifs are correlated by MISCORE. As the promoter region grows in length from 200bp to 500bp, the ORS r (M t ) scores tend to increase as anticipated. Note: L fg denotes the length of the promoter sequences.
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BMC Systems Biology

ISSN: 1752-0509

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