Figure 2
From: A cross-species analysis method to analyze animal models' similarity to human's disease state
Workflow of our analysis method. The cMap database of chemical interventions was used for search. Given an animal model query profile with gene id and expression value (treated/control), every animal gene id was converted to orthologous human gene id. Through differential expressed gene GO enrichment and KS-test with cMap database, a result was returned with a table of top 10 molecules which were most similar to that of the query profile, and their similar GO modules, positive or negative.