Figure 1

Schematic representation of the ODE model. Compartments representing cell types and growth factors are depicted as boxes (s. Table 1). Compartment MGB is substructured into G4-6 to model maturation with Γ-distributed transit times. Cell fluxes between compartments are shown as black arrows, the effect of chemotherapy as gray arrows with associated kill rate k_X indicated by a label and feedbacks as colored arrows: intrinsic stem cell feedback (red), feedback from bone-marrow cells to stem cells (green) and feedback between later stages of granulopoiesis mediated by explicitly modeled growth-factors (blue). The colored arrows indicate the input for the feedback functions (s. Appendix A2.1) that dynamically control compartment parameters mentioned by the labels.