Figure 4

Simulations of bone marrow transplantation with G-CSF support after myeloablative conditioning. All bone marrow compartments were initialized with 1%, only GRA with 50% of its equilibrium value. We present relative cell numbers throughout. a) In the ODE model, S repopulates 50% after 18d and 100% after 60d. GRA repopulates 50% after 6d and 100% after 7d. b) Both GEs in the SCC of the hybrid model are reduced. Repopulation is slow and not completed after 100d. c) Stem cell reduction is limited to the proliferative GE Ω. S repopulates 98% in 5 days, PGB and GRA 100% after 9.5d. The other compartments repopulate within the next 40 days.