Figure 9

Preliminary simulation of myeloablative bone marrow transplant with modified transition characteristics. While keeping the equilibrium values of the transition characteristics nearly unchanged, for smaller cell numbers N_Α and N_Ω the transition characteristics increase much stronger than for the established human parameter set. The more dynamic switching behavior results effectively in stem cell activation and much faster recovery. Stem cells repopulate completely after 31 days and GRA recovers 25% of its equilibrium value after 36 days. Again G-CSF application was continued until the recovery of GRA.