Skip to main content

Table 3 Top 10 genes, TFs, and miRNAs with highest in-degree in lung cancer synergistic regulatory network

From: Functional analysis of microRNA and transcription factor synergistic regulatory network based on identifying regulatory motifs in non-small cell lung cancer

Top Gene In- degree Supported bya
1 NTRK2 153 PMID: 21466358
2 ACVR2B 146 -
3 PLAG1 142 -
4 RAPH1 131 -
5 IGF1R 127 PMID: 22133293
6 CLCN5 123 -
7 FOXP1 123 PMID: 22904134
8 ACSL4 120 -
9 WHSC1 120 PMID: 22028615
10 ABHD2 120 -
1 E2F3 112 PMID: 16938365
2 ESR1 110 PMID: 18949413
3 PPARA 79 -
4 SMAD7 75 PMID: 21221812
5 ETS1 68 PMID: 17785952
6 MAFG 62 -
7 ETS2 56 PMID: 21922129
8 ARNT 54 PMID: 22645320
9 AHR 53 PMID: 21646808
10 FUBP1 51 PMID: 19258502
1 hsa-miR-129-5p 7 -
2 hsa-miR-19b 7 -
3 hsa-miR-219-5p 7 PMID: 16530703
4 hsa-miR-92a 7 -
5 hsa-miR-301b 6 -
6 hsa-miR-433 6 -
7 hsa-miR-557 6 -
8 hsa-miR-152 5 -
9 hsa-miR-16 5 PMID: 19549910
10 hsa-miR-329 5 -
11 hsa-miR-429 5 PMID: 19759262
  1. aSupported by: published articles in which the gene, TF, or miRNA was experimentally verified as being related to lung cancer development and progression.