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Table 5 Examples of motifs or prognosis components of motifs

From: Functional analysis of microRNA and transcription factor synergistic regulatory network based on identifying regulatory motifs in non-small cell lung cancer

Motif

Example

Supported bya

Prognosis

Supported by

P-valueb

I

miR-106a& E2F1

PMID: 18521848

miR-106a &E2F1 &RAD51

PMID:20219352&16166473 &15956972

0.03790692

II

miR-27b& ESR1

-

miR-181a &TP53 &RUNX3

PMID:20363096&17401424 &15819721

0.001892851

III

miR-16& MYC

PMID: 22002311

miR-16 &JUN &LPL

PMID:21400525&9484827 &21508119

3.311478e-06

IV

miR-106a& E2F1

PMID: 22002038

miR-17 &STAT1 &ALDH1A3

PMID:22065543&20581241 &22960273

1.80563e-21

V

miR-17& E2F1

PMID: 18171346

miR-21 &ESR1 &CXCL12

PMID:20508945&20109227

0.006603943

VI

miR-548& MYC

-

Let-7d &ATF1 &GSTP1

PMID:21725603&22631637 &22045684

3.35018e-07

VII

miR-20b& ESR1

PMID: 22002038

miR-200c &E2F3 &ALDH1A3

PMID:20579395&15122326 &23436614

6.592982e-22

VIII

miR-152& POU2F1

PMID: 21712563

miR-141 &SOX2 & CXCL12

PMID:21445232&20532662 &16631235

1.471662e-21

IX

miR-19a& ESR1

PMID: 20080637

CTNNB1 & miR-21 & SMAD7

PMID:17949785&20508945 &12584741

0.0002268908

X

miR-34c-5p& MYC

PMID: 22585994

GADD45A& miR-34 & P53

PMID:12171872&19736307 &22978804

2.885798e-06

  1. aSupported by: published articles in which the gene, TF, or miRNA was experimentally verified as working together or have a prognosis function.
  2. bP-value: the P-value of hypergeometric cumulative distribution to test whether the motifs were enriched with gene mutations.