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Table 1 List of reactions and metabolites in the network

From: Kinetic modelling of phospholipid synthesis in Plasmodium knowlesi unravels crucial steps and relative importance of multiple pathways

Reaction ID Substrates & products Enzyme (E.C number) ORF (P.falciparum/P.knowlesi) References
R1 SerE → Ser ? ? [28]
  (Serine transport)    
R2 Ser → PS PSS (MAL8P1.58) /(PKH_051100) Vial (unpublished data).
  (Phosphatidylserine synthesis)   predicted  
R3 Ser → Etn SD ? [28]
  (Serine decarboxylation) 4.1.1   
R4 Etn → PEtn EK PfEK [29]
  (Ethanolamine phosphorylation) 2.7.1.82 (PF11_0257) /(PKH_092210)  
R5 PEtn → PCho PMT PfPMT [30, 31]
  (Phosphoethanolamine methylation) 2.1.1.103 (MAL13P1.214) / (PKH_121150)  
R6 PS → PE PSD PfPSD [32]
  (Phosphatidylserine decarboxylation) 4.1.1.65 (PFI1370c) /(PKH_072580)  
R7 PEtn → PE ECT PfECT [28, 33]
   2.7.7.14 (PF13_0253)/ (PKH_120620)  
   CEPT/EPT PfCEPT  
   2.7.8.1 (PFF1375c)/(PKH_112100)  
R8 PCho → PC CCT PfCCT [3335]
   2.7.7.15 (MAL13P1.86)/(PKH_141580)  
   CEPT/CPT PfCEPT  
   2.7.8.2 (PFF1375c)/(PKH_112100)  
R9 PE → PC PEMT/PLMT ? [28, 36, 37]
  (Methylation) 2.1.1.17/2.1.1.71   
R10 PC → PS PSSbe (MAL13P1.335) /(PKH_110380)  
  (base exchange) 2.7.8   
R11 PE → PS PSSbe (MAL13P1.335) /(PKH_110380)  
  (base exchange) 2.7.8   Berry and Vial (unpublished data)
R12 PC → ? ?  
  (Phosphatidylcholine efflux)    
R13 PS → ? ?  
  (Phosphatidylserine efflux)    
R14 PE → ? ?  
  (Phosphatidylethanolamine efflux)    
R15 ChoE → Cho NPP/OCT/CTL (PFE0825w) /(PKH_101630) [20, 3840]
  (Choline transport)    
R16 Cho → PCho CK PfCK [29, 41]
  (Choline phosphorylation) 2.7.1.32   
R17 EtnE → Etn   ?  
  (Ethanolamine diffusion)    
  1. We have used the following abbreviations. SerE = exogenous serine, Ser = intracellular serine, PS = phosphatidylserine, EtnE = exogenous ethanolamine, Etn = intracellullar ethanolamine, PEtn = phosphoethanolamine, PE = phosphatidylethanolamine, ChoE = exogenous choline, Cho = intracellular choline, PCho = phosphocholine, PC = phosphatidylcholine, DAG = diacylglycerol, SD = serine decarboxylase, PSSbe = phosphatidylserine synthase I, PMT = phosphoethanolamine-N-methyltransferase, PEMT = phosphophatidylethanolamine-N-methyltransferase, CCT = cholinephosphate cytidylyl transferase, ECT = ethanolaminephosphate cytidylyl transferase, CEPT = choline/ethanolamine phosphotransferase, CK = choline kinase, EK = ethanolamine kinase, NPP = New permeation pathway, OCT = Organic cationic transporter, ? = putative genes found.
  2. This model was deposited in BioModels Database [42] and assigned the identifier MODEL1310130000.
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