MC3: a steady-state model and constraint consistency checker for biochemical networks

BMC Systems Biology

Table 2 Summary of applying MC ³ to several published models

Model	(a) Metabolites	(b) Reactions	(c) Exchange reactions	(d) Reversible reactions	(e) SCM	(f) DEM	(g) ZFR	(h) UR	(i) CR	(j) RCR
Minimal E. Coli	53	70	15	19	2	2	3	8	14	0
E. Coli iJR904	761	1075	143	388	56	67	150	196	325	8
E. Coli iAF1260	1668	2382	299	852	87	118	184	461	970	32
adipocyte	26	34	7	0	0	0	0	0	10	0
CHO cell	231	275	34	108	0	0	0	53	540	0
Leishmania major	1101	1112	64	630	250	259	376	374	156	9

For each model, the number of metabolites, reactions, exchange reactions and reversible reactions are indicated in columns a-d. The results of applying MC³ are indicated in columns: (e) Singly Connected Metabolites (SCM), (f) Dead-End Metabolites (DEM), (g) Zero-Flux Reactions (ZFR), (h) Unsatisfied Reversibility (UR), (i) Coupled Reactions (CR), and (j) Reversibly Coupled Reactions (RCR).

ISSN: 1752-0509