Figure 6

Example of randomly generated network preserving E. coli topological characteristics. Perturbation (red pointer) of reprogramming determinants induced the transition from Attractor 0 to Attractor 6. This network includes 25 nodes and 60 interactions. The stability analysis assuming a Boolean dynamical model and a synchronous updating scheme detected 8 stable steady states, so there are 16 possible transitions between them. The transition is achieved after the perturbation of CPXR, CSGD, RCSA and BAER. Such perturbation targets all DEPCs between represented attractors. Genes in “ON” and “OFF” are represented in grey and white respectively. Regular arrows represent activation and T-arrows represent inhibitions.