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Table 1 Minimal combinations of reprogramming determinant genes obtained after the application of our method in five different biological examples for specific transition between attractors corresponding to cellular phenotypes

From: Detecting cellular reprogramming determinants by differential stability analysis of gene regulatory networks

Example Transitions DEPFCs Minimal combinations of reprogramming determinant genes
T-helper Th2-Th1 4 GATA3, T-bet
EMT Epithelial-Mesenchymal 12 SNAI1, ZEB2, MIR203
HL60 HL60-Neutrophil 1 IL1B, CASP1, IRF1
iHEP Fibroblast-Hepatocyte 2 FOXA2:PPARGC1A,NR5A2:UCP2, HNF1A:PPARGC1A,HNF4A:NR5A2, NR5A2:PPARGC1A, FOXA2:HNF4A, HNF1A:UCP2, AGT:NR5A2,AGT:FOXA2,FOXA2:UCP2, AGT:HNF1A, HNF1A:HNF4A
iCM Fibroblast-Cardiomyocyte 2 GATA4, MEF2C
iPSCS Fibroblast-iPSCS 7 MYC:POU5F1:SOX2, POU5F1:SOX2:mir-107,MYB:POU5F1:SOX2, ATF3:POU5F1:SOX2,POU5F1:SOX2:TP53,
  1. Genes in bold correspond with those whose perturbation are represented in FigureĀ 5.
  2. Alternative combinations of reprogramming determinant genes are separated by comma. Combinations of reprogramming determinants genes perturbed in FigureĀ 6 are in bold.