Figure 3

Receptor activation dynamics under different parameterisation of the module. The figure shows the total phosphorylated receptor (IRE1A) with respect to the total unfolded protein (UFPT). The grey solid curve corresponds to the reference parameter set given in Additional file 1: Text 1.1. The grey dashed curve describes the change from this when the rate of association and the stoichiometry of the activated complex are increased. The dark dotted and dashed curves refer to the effect of UFP stabilisation of the activated complex or its involvement in the direct activation, respectively.