Functional inter-connectivity of autism genes. Functional inter-connectivity of autism genes, predicted by GAP (7a), GeneMANIA (7b), and STRING (7c), and reported in the databases of experimentally validated direct and indirect interactions according to our gold standard dataset (7d). The transparency of the edges in graphs predicted by GAP, GeneMANIA, and STRING is inversely proportional to the score of the predicted associations; the top 10% of the highest-ranked predicted interactions are colored in red. The size of each node is proportional to the node degree. In Figure 7d, red lines show direct (physical) interactions, and the rest are pathway co-membership associations.