Figure 2

Comparison of functional feedback networks and coupled local and global feedback circuits between two groups. (A) (Left and Middle) Total number of positive feedback connections in the normal and schizophrenia patients groups, and (Right) bar plot of the total number of positive feedback connections. Patients group exhibits the reduced number of positive feedback connections (p = 0.042). (B) (Top row) The number of global and (Bottom row) local positive feedback connections in the normal and schizophrenia patients groups. The reduced number of local positive feedback connections can be seen in the patients group (p = 0.0036). (C) (Left) Coupled local and global feedback circuits existing in the cortical functional network and (Right) statistical comparison of the number of this circuit in the normal and schizophrenia patients groups. Coupled local and global feedback circuits are reduced in the patients group (p = 0.031). Bars and vertical lines denote mean and standard errors, respectively.