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Table 2 Split ratios of ATP-consuming fluxes

From: A metabolite-centric view on flux distributions in genome-scale metabolic models

Consuming fluxes
Reaction/Enzyme Pathway/Product Ratio
Biomass (incl. GAM)   66.39%
phosphofructokinase glycolysis 8.77%
ATP maintenance requirement NGAM 4.52%
adenylate kinase AMP→ADP 2.73%
acetyl-CoA carboxylase fatty acids 2.68%
AICAR biosynthesis from PRPP (5 reactions) purines 2.67%
glutamine synthetase Gln 2.13%
aspartate kinase Thr, Met, Lys, peptidoglycans 1.28%
PRPP synthetase pentose phosphate pathway 1.11%
nucleoside-diphosphate kinase GTP 0.92%
carbamate kinase pyrimidines, Arg, polyamines 0.75%
homoserine kinase Thr 0.65%
nucleoside-diphosphate kinase UTP 0.49%
shikimate kinase shikimate pathway 0.46%
UMP kinase pyrimidines 0.44%
acetylglutamate kinase Arg, polyamines 0.40%
argininosuccinate synthase Arg 0.35%
adenylyl-sulfate kinase sulfur metabolism 0.30%
sulfate adenyltransferase sulfur metabolism 0.30%
guanylate kinase purines 0.29%
GMP synthase purines 0.29%
asparagine synthetase Asn 0.29%
glutamate 5-kinase Pro 0.26%
cytidylate kinase pyrimidines 0.20%
CTP synthase (glutamine) pyrimidines 0.19%
glucose-1-phosphate adenylyltransferase glycogen 0.19%
nucleoside-diphosphate kinase CTP 0.17%
6 reactions in cell wall biosynthesis peptidoglycans 0.17%
7 reactions in lipopolysaccharide biosynthesis lipopolysaccharides 0.13%
phospholipid export (2×3 reactions) phospholipids 0.11%
ATP phosphoribosyltransferase His, purines 0.11%
  1. Total flux: 69.7 mmol gDW−1 h−1. Ratios below 0.05% not shown.
  2. Abbreviations: AICAR – 5-aminoimidazole-4-carboxamide ribotide, Arg, Asn, … – biosynthesis of L-amino acids, PRPP – phosphoribosyl pyrophosphate.