Table 2 Split ratios of ATP-consuming fluxes
From: A metabolite-centric view on flux distributions in genome-scale metabolic models
Consuming fluxes | ||
|---|---|---|
Reaction/Enzyme | Pathway/Product | Ratio |
Biomass (incl. GAM) | Â | 66.39% |
phosphofructokinase | glycolysis | 8.77% |
ATP maintenance requirement | NGAM | 4.52% |
adenylate kinase | AMP→ADP | 2.73% |
acetyl-CoA carboxylase | fatty acids | 2.68% |
AICAR biosynthesis from PRPP (5 reactions) | purines | 2.67% |
glutamine synthetase | Gln | 2.13% |
aspartate kinase | Thr, Met, Lys, peptidoglycans | 1.28% |
PRPP synthetase | pentose phosphate pathway | 1.11% |
nucleoside-diphosphate kinase | GTP | 0.92% |
carbamate kinase | pyrimidines, Arg, polyamines | 0.75% |
homoserine kinase | Thr | 0.65% |
nucleoside-diphosphate kinase | UTP | 0.49% |
shikimate kinase | shikimate pathway | 0.46% |
UMP kinase | pyrimidines | 0.44% |
acetylglutamate kinase | Arg, polyamines | 0.40% |
argininosuccinate synthase | Arg | 0.35% |
adenylyl-sulfate kinase | sulfur metabolism | 0.30% |
sulfate adenyltransferase | sulfur metabolism | 0.30% |
guanylate kinase | purines | 0.29% |
GMP synthase | purines | 0.29% |
asparagine synthetase | Asn | 0.29% |
glutamate 5-kinase | Pro | 0.26% |
cytidylate kinase | pyrimidines | 0.20% |
CTP synthase (glutamine) | pyrimidines | 0.19% |
glucose-1-phosphate adenylyltransferase | glycogen | 0.19% |
nucleoside-diphosphate kinase | CTP | 0.17% |
6 reactions in cell wall biosynthesis | peptidoglycans | 0.17% |
7 reactions in lipopolysaccharide biosynthesis | lipopolysaccharides | 0.13% |
phospholipid export (2Ă—3 reactions) | phospholipids | 0.11% |
ATP phosphoribosyltransferase | His, purines | 0.11% |