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Table 7 Split ratios of L-glutamate

From: A metabolite-centric view on flux distributions in genome-scale metabolic models

Producing fluxes
Reaction/Enzyme Pathway/Product Ratio
glutamate dehydrogenase TCA cycle 85.02%
amidophosphoribosyltransferase purines 4.40%
phosphoribosylformylglycinamidine synthase purines 4.40%
GMP synthase purines 2.39%
CTP synthase CTP 1.57%
imidazole-glycerol-3-phosphate synthase His, purines 0.93%
glutamine-fructose-6-phosphate transaminase peptidoglycans, lipopolysaccharides 0.72%
anthranilate synthase Trp 0.56%
Consuming fluxes
Reaction/Enzyme Pathway/Product Ratio
aspartate transaminase Asp 28.82%
glutamine synthetase Gln 17.57%
phosphoserine transaminase Ser 17.15%
L-alanine transaminase Ala 5.55%
leucine transaminase Leu 4.43%
valine transaminase Val 4.16%
succinyldiaminopimelate transaminase Lys, peptidoglycans 3.65%
N-acetylglutamate synthase Arg, polyamines 3.31%
acetylornithine transaminase Arg, polyamines 3.31%
isoleucine transaminase Ile 2.85%
Biomass   2.59%
glutamate 5-kinase Pro 2.17%
phenylalanine transaminase Phe 1.82%
tyrosine transaminase Tyr 1.36%
histidinol-phosphate transaminase His 0.93%
glutamate racemase peptidoglycans 0.28%
glutamyl-tRNA synthetase cobalamin, heme 0.05%
  1. Total flux: 8.46 mmol gDW−1 h−1. Ratios below 0.05% not shown.
  2. Abbreviations: Ala, Arg, … – biosynthesis of L-amino acids.