Table 2 Parameters defined in the model

Synthesis, dimension =/hour

s _ime1

Synthesis rate of Ime1

10

[15, 43–45]

s _ime2

Synthesis rate of Ime2

10

[39]

s ^’ _ime2

The maximum rate of auto-regulation-dependent Ime2 synthesis

3

Estimated

Degradation, dimension =/hour

d _ime1

Degradation rate of Ime1

1

[3]

d ^’ _ime1

The maximum rate of Ime2-activated Ime1 degradation

1

[3]

d _pime1

Degradation rate of pIme1

1

[3]

d _ime2

Degradation rate of Ime2

8

[3]

Phosphorylation, dimension =/hour

p _rim11

Phosphorylation rate of Rim11

0.01

[2], Estimated

u _rim11

Dephosphorylation rate of Rim11

0.1

[2], Estimated

p _ume6

Phosphorylation rate of Ume6

0.3

[18], Estimated

u _ume6

Dephosphorylation rate of Ume6

0.01

[18], Estimated

p _sok2

Phosphorylation rate of Sok2

0.7

[6], Estimated

u _sok2

Dephosphorylation rate of Sok2

1

[6], Estimated

p _ime1

Phosphorylation rate of Ime1

2

Estimated

Constant, dimensionless

c _sok2

Constant measuring half-maximum inhibition of Sok2 phosphorylation by Ime1

0.05

Estimated

c _ime1

Constant measuring half-maximum inhibition of Ime1 synthesis by pSok2

0.01

Estimated

c ₁

Constant measuring half-maximum activation of Ime1 degradation by Ime2

0.01

Estimated

c ₂

Constant measuring half-maximum activation of Ime2 synthesis through auto-regulation

1.4

Estimated

c ₃

Constant measuring half-maximum activation of Ime2 degradation

2

Estimated