Validation of a model of the GAL regulatory system via robustness analysis of its bistability characteristics

BMC Systems Biology

Table 2 A set of parameters values that renders system (1) bistable

Parameter	Value	Parameter	Value
k ₁	0.1814 [ μ M·h]	k ₁₁	85.8185 [1/h]
k ₂	8.4586E-4 [1/ μ M·h]	k _{r 11}	4.7482E-2 [1/ μ M·h]
k _{r 2}	16.6691 [1/h]	μ ₁₂	1.0 [1/h]
μ ₃	1.0 [1/h]	μ ₁₃	1.0 [1/h]
k ₄	3.0749 [1/ μ M·h]	μ ₁₄	1.0 [1/h]
k _{r 4}	0.1317 [1/h]	μ ₁₅	1.0 [1/h]
k ₅	22.0604 [ μ M/h]	μ ₁₆	1.0 [1/h]
μ ₆	1.0 [1/h]	μ ₁₇	1.0 [1/h]
k ₇	29.6549 [1/h]	μ ₁₈	1.0 [1/h]
k ₈	181.4157 [1/h]	k ₁₉	36.6342 [1/ μ M·h]
k ₉	1.0 [1/h]	k _{r 19}	222.0536 [1/h]
k ₁₀	1.0 [1/h]

The values have been computed through the CRNT algorithm and then scaled to suitable dimensions (see the results Section ‘Structural analysis of the proposed model’s network topology confirms bistable dynamics’).

ISSN: 1752-0509