Modeling mutant phenotypes and oscillatory dynamics in the Saccharomyces cerevisiae cAMP-PKA pathway

BMC Systems Biology

Table 1 Parameter values that vary when fitting Equations (4a)–(4d) to the Ma et al. data

Parameter	wt	pde1Δ	pde2Δ	pde1Δ ^ala152	pde1Δ pde2Δ
M	0.01	0.0005	0.01	0.0025	–
D	1	0.26	1	0.54	–
Γ	33.6	16.8	33.6	33.6	–
B	.0051	.0051	.0051	.0051	.51

Here M is the quantitative expression of Condition (b) [see text]; D represents enhanced decay due to PKA feedback on Pde modified by Γ, the affinity of activated Pde for cAMP; B is the inactivation rate of Ras ·GTP due to Ira1/2. Also see the text for a discussion of the great overlap between columns 2 and 4.

ISSN: 1752-0509