Extension of the MHB signaling model by miRNA regulation. (A)Illustration of the three considered miRNA regulation scenarios. Boxes describethe encoding gene, black dots represent the mature miRNA and the curved linesrepresent the transcribed mRNA. The parametersα
, α4,κ and ξ are the parameters considered in themodel. (B) Graph of extended regulatory network. (C) Sharpeningof the Wnt1 expression domain for a given miRNA expression profileparameters for the simulations given in (D). Each plot corresponds tothe scenario above it. (D) Wnt1 expression level depending onmiRNA expression profile. The expression profile is varied by the parameterl, which determines the size of the overlay with the Wnt1expression domain. For all simulations we used the same parameters for theoriginal MHB model as in Figure 2B. (E) MiRNAexpression level and its dependence on the parameter l.