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Table 3 The 20 most fragile phenotypes

From: Optimization and model reduction in the high dimensional parameter space of a budding yeast cell cycle model

Strain name Phenotype Percent of total losses
CLB2-db Δ multicopy SIC1 Viable 3.38
cln1 Δ cln2 Δ cdh1 Δ Viable 3.19
CLB2-db Δ clb5 Δ clb6 Δ in galactose Viable 3.16
cdc15 Δ net1-ts cdh1 Δ Viable 2.85
GAL-CLB2 cdh1 Δ Inviable 2.84
cln1 Δ cln2 Δ cdh1 Δ GAL-CLN2 Viable 2.74
CLB2-db Δ in galactose Inviable 2.70
APC-A Viable 2.40
APC-A sic1 Δ Viable 2.39
CLB5-db Δ pds1 Δ Viable 2.35
APC-A cdh1 Δ multicopy SIC1 Viable 2.31
cdh1 Δ Viable 2.24
cln1 Δ cln2 Δ cln3 Δ sic Δ Viable 2.03
bck2 Δ Viable 1.93
GALL-CDC20 sic1 Δ cdh1 Δ Viable 1.84
APC-A cdh1 Δ in galactose Inviable 1.72
clb5 Δ clb6 Δ cdc20 Δ pds1 Δ Viable 1.69
cln3 Δ bck2 Δ sic Δ Inviable 1.67
cln1 Δ cln2 Δ Viable 1.54
APC-A sic1 Δ cdc6 Δ2-49 Viable 1.53
  1. These are the phenotypes that are most often lost (i.e., incorrectly simulated) when perturbations are applied to individual model parameters. Fragility decreases from top to bottom.