Optimization and model reduction in the high dimensional parameter space of a budding yeast cell cycle model

BMC Systems Biology

Table 3 The 20 most fragile phenotypes

Strain name	Phenotype	Percent of total losses
CLB2-db Δ multicopy SIC1	Viable	3.38
cln1 Δ cln2 Δ cdh1 Δ	Viable	3.19
CLB2-db Δ clb5 Δ clb6 Δ in galactose	Viable	3.16
cdc15 Δ net1-ts cdh1 Δ	Viable	2.85
GAL-CLB2 cdh1 Δ	Inviable	2.84
cln1 Δ cln2 Δ cdh1 Δ GAL-CLN2	Viable	2.74
CLB2-db Δ in galactose	Inviable	2.70
APC-A	Viable	2.40
APC-A sic1 Δ	Viable	2.39
CLB5-db Δ pds1 Δ	Viable	2.35
APC-A cdh1 Δ multicopy SIC1	Viable	2.31
cdh1 Δ	Viable	2.24
cln1 Δ cln2 Δ cln3 Δ sic Δ	Viable	2.03
bck2 Δ	Viable	1.93
GALL-CDC20 sic1 Δ cdh1 Δ	Viable	1.84
APC-A cdh1 Δ in galactose	Inviable	1.72
clb5 Δ clb6 Δ cdc20 Δ pds1 Δ	Viable	1.69
cln3 Δ bck2 Δ sic Δ	Inviable	1.67
cln1 Δ cln2 Δ	Viable	1.54
APC-A sic1 Δ cdc6 Δ2-49	Viable	1.53

These are the phenotypes that are most often lost (i.e., incorrectly simulated) when perturbations are applied to individual model parameters. Fragility decreases from top to bottom.

ISSN: 1752-0509