Figure 3

Time-dependent expression profiles in the follicle. Simulated and measured expression levels of LH receptor in granulosa and theca, and of the FSH receptor and the aromatase in the granulosa during the 1st wave of the bovine follicle maturation process. The data was recorded by[15, 16]. The lower curves that extend to 10 days are the measurements in[16]; the follicles in these measurements were growing more slowly than in the study by[15]. Note that the dominant follicle undergoes atresia from day 6. (A) Data (dotted lines) and simulation predictions (solid line) of LH receptor expression in the theca. (B) Data (dotted lines) and simulation predictions (solid line) of LH receptor expression in the granulosa. (C) Data (dotted lines) and simulation predictions (solid line) of FSH receptor expression in the granulosa. (D) Data (dotted lines) and simulation predictions (solid line) of aromatase expression in the granulosa. The shaded area indicates the standard deviation of the simulations when noise is applied to the parameter values.