Figure 4
From: Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice
Profiles of Magnitude Coefficients and Velocity Coefficients for the different viruses and dosage conditions. (A) Variation of Magnitude Coefficients over time for the different viruses. (B) Variation of Velocity Coefficients over time for the different viruses. Profiles are colored by viral strain and line types represent the different doses. The Magnitude Coefficient (MC) quantifies the magnitude effect as the transcriptomic or proteomic distance from one biological condition to the matched mock-infected condition. The Velocity Coefficient (VC) quantifies the velocity effect as the speed of the transcriptomic host response to move from one time point to the next one. Both the MC and VC were calculated based on the centroids of the biological conditions and the transcriptomic or proteomic distances are calculated based on the lists of transcripts associated with the kinetics of the host response to VN1203 wild-type.