Figure 5

Identifiability comparison of two model structures. (A) Bootstrap parameter estimations on two model structures using literature time-series data with estimated errors (box plots). Resulting regions of model trajectories are shaded between the 5 ^th and 95 ^th percentile. Per species are shown in purple, Cry1 in red, and Cry2 in green. While both models were able to approximately reproduce the same dynamic response, the expanded model was better able to capture differences between the Cry1 and Cry2 profiles. (B) Parameter and sensitivity identifiability for the base and expanded models. Violin plots show the parameter and sensitivity distributions, with unidentifiable sensitivities (90% confidence level) highlighted in red. Despite containing more parameters, the expanded model shows better parameter identifiability and higher confidence in its predicted sensitivities. The PER translation rate (1) and PER-CRY association rate (2) sensitivities are consistent across model equations and are highlighted.