New network topology approaches reveal differential correlation patterns in breast cancer

BMC Systems Biology

Table 3 Gene enrichment analysis (ER+ vs. ER-)

Category	Catalog	DCloc		DCglob
		N	p	N	p
Extracellular matrix	GOTERM_CC_FAT	60	9.6E-13	29	2.8E-01
Cell adhesion	GOTERM_BP_FAT	80	2.0E-07	43	5.5E-01
Cell cycle	GOTERM_BP_FAT	79	2.2E-05	63	3.7E-03
Immune response	GOTERM_BP_FAT	70	6.4E-05		n.s.
Growth factor binding	GOTERM_MF_FAT	22	1.5E-04		n.s.
Organelle fission	GOTERM_BP_FAT	30	1.6E-03	24	4.2E-02
ECM-receptor interaction	KEGG_PATHWAY	18	3.9E-03		n.s.
Ribosome	KEGG_PATHWAY	18	5.5E-03		n.s.
Oxidoreductase	SP_PIR_KEYWORDS	42	8.3E-02	42	2.2E-02

The table shows the most significantly enriched biological themes in the lists of 770 (DCloc) and 630 (DCglob) DC genes. For each functional category, the number of genes in the category (N) and the significance of enrichment (Benjamini-Hochberg corrected p-value) are shown. Some of the findings of DCglob are not significant (n.s.).

ISSN: 1752-0509